We are proceeding our research for educating dental hygienist with higher knowledge and critical thinking, in particular focused on basic research. Since our motive is it needs the scientific evidence for providing the proper oral health management by dental hygienists, our research is  focused on the roles of oral microorganisms (bacteria and fungi) on systemic diseases including diabetes and cancer. Our perspective in the future is that the results by basic research we have ever found will be connected to the clinical research and social implementation.